Patrik Danielson

Patrik DanielsonTitle: Professor/Consultant (Professor/Överläkare)

Degrees: M.D., Ph.D.

Address: Dept. of Integrative Medical Biology,
Umeå University, SE-901 87 Umeå, Sweden

Phone: +46 (0)90 786 58 93 (office)
+46 (0)70 336 80 30 (mobile)

Fax: +46 (0)90 786 66 83

E-mail: patrik.danielsonumu.se

Professor Danielson is Deputy Dean of the Faculty of Medicine.

Curriculum VitaeResearch TeamPublicationsResearch Projects (information available in both English and Swedish)Populärvetenskaplig sammanfattning inkl. video (SVENSKA)Grants

Patrik Danielson is Professor of Anatomy at Umeå University and works in parallel as a consultant/attending ophthalmologist at the Centre for Ophthalmology/Ophthalmic surgery at the University Hospital of Umeå. He is the principal investigator of the experimental tendon and cornea research projects at the Department of Integrative Medical Biology.

Professor Danielson's research revolves diseases in collagen rich tissues, with focus on muscle tendons and the cornea of the eye. The aim of this research is to unravel the possible roles of locally produced signal substances, traditionally attributed to neuronal signalling mechanisms, in the development of connective tissue pathology.
This research is performed in collaboration with the University of British Columbia, Vancouver, Canada (Assist. Prof. Alex Scott), and the Shandong Eye Institute, Qingdao, China (Assoc. Prof. Qingjun Zhou).
Read more about this research in the university's research database (information in both Swedish and English is available) or in the scientific publications listed on this site.


[Photo by Jan Alfredsson]

CURRICULUM VITAE – Patrik Danielson

Professional Preparation and Academic Appointments:
2005 Medical Degree (M.D.), Umeå University [sv. läkarexamen]
2007 Medical License (Registered Physician with the Swedish National Board of Health and Welfare) [sv. leg. läkare]
2007 Doctor of Philosophy, Medicine (Ph.D.), Umeå University
[sv. Med.dr]
2008 Acting Senior lecturer/Assoc. prof. [sv. vik. universitetslektor]
2009 Senior lecturer/Assoc. professor [sv. universitetslektor]
2012 Reader/Assoc. professor [sv. docent]
2014 Professor (full)
2016 Consultant/Attending Ophthalmologist
[sv. överläkare, specialist i ögonsjukdomar]

Awards and Honours:
2013 The Swedish Society of Medicine's Best Translational Research Award
2011 Umeå University Young Researcher Award
2010 The Royal Skytteanska Society's Distinguished Young Researcher 
Award in Medicine
2009 "Terminens Ros" Läkarprogrammet termin 3 (ht09)
2008 Recipient of Post-doc Scholarship from the Muscle Fund North Foundation
2007 Honorary Member of the Medical Sciences Student Union, Umeå University

External Research Grants as Main Applicant (1 000 SEK):
Sponsor 2010 2011 2012 2013 2014 2015 2016 2017
Vetenskapsrådet * 700 700 700 1 261 1 261 1 261 1 261
Swedish Society of Medicine (SLS) 135 230 452 175 200
Cronqvists stiftelse 150 115 125 250
Kempestiftelserna 189 252 200
Centrum för Idrottsforskning (CIF) 25 75 75 55
Stiftelsen KMA 40 104 200
Tore Nilssons stiftelse 60 60
Magn. Bergvalls stiftelse 50 50
Goljes stiftelse 50
Ögonfonden 40
Saléns stiftelse 80

 *) National Swedish Research Council

University/County Council Grants Awarded in Competition (1 000 SEK):
Type of Grant 2010 2011 2012 2013 2014 2015 2016 2017 2018
Faculty Co-financing of PhD-
student [samfinans]
250 250 500 500 250 250
Young Researcher Award 2011 500 1 000 500
Central calls for ALF-medel (Federal funds for medical research through the County Council) 400 350 350 500 500 500
ALF Investeringsmedel (Federal funds for medical research through the County Council; Investments in infrastructure) 120 200
County Council (VLL) 'Spjutspetsmedel' 870 870 870

Commissions of Trust:
2015- Member of the Board of the Swedish Society of Medicine
2014- Deputy Dean of the Faculty of Medicine, Umeå University
2014- Vice Chair of the Faculty Board, Faculty of Medicine, Umeå University
2014- Chair of the Board for Strategic Planning of Faculty Staffing, Faculty of Medicine, Umeå University
2014- Chair of the Budget Committee, Faculty of Medicine, Umeå University
2008- Member of the Editorial Board, the Journal of Science and Medicine in Sport (JSAMS)
2011-2014 Member of the Faculty Board, Faculty of Medicine, Umeå University (elected faculty representative)
2009-2014 Member of the Board, Stiftelsen Muskelfond Norr ("Muscle Fund North Foundation")
2003-2005 Member of the Board of Directors, the Studenthälsan Foundation, Umeå (Executive Board Member 2003-2004, Permanent Secretary 2005)
2002-2004 Member of the Board of Directors for Umeå University
(student representative)
2001-2004 Member of the Faculty Board, Faculty of Medicine, Umeå University (student representative)
2005 Chairman of the Student Senate, Medical Sciences Student Union, Umeå University
2002-2004 President of the Medical Sciences Student Union, Umeå University

LIST of PUBLICATIONS – Prof. Patrik Danielson, MD, PhD
 

Link to Google Scholar Profile


Peer-reviewed publications in international scientific journals:
 

Fong G, Backman LJ, Alfredson H, Scott A, and Danielson P: The Effects of Substance P and Acetylcholine on Human Tenocyte Proliferation Converge Mechanistically via TGF-β1. PLOS ONE 2017; 12(3): e0174101. [Link

Chen J, Lan J, Liu D, Backman LJ, Zhang W, Zhou Q and Danielson P: Ascorbic Acid Promotes the Stemness of Corneal Epithelial Stem/progenitor Cells and Accelerates Epithelial Wound Healing in the Cornea. Stem Cell Transl Med 2017; published online ahead of print March 9. doi:10.1002/sctm.16-0441 [Link]

Zhang W, Chen J, Backman LJ, Malm AD, and Danielson P: Surface Topography and Mechanical Strain Promote Keratocyte Phenotype and Extracellular Matrix Formation in a Biomimetic 3D Corneal Model. Adv Healthc Mater 2017; 6, 1601238 [Link]

Słoniecka M, Backman LJ, and Danielson P: Antiapoptotic effect of acetylcholine in Fas-induced apoptosis in human keratocytes. Invest Ophthalmol Vis Sci (IOVS) 2016; 57; 5892-5902 [Link]

Chen J, Chen P, Backman LJ, Zhou Q and Danielson P: Ciliary neurotrophic factor promotes the migration of corneal epithelial stem/progenitor cells by up-regulation of MMPs through the phosphorylation of Akt. Scientific Reports 2016; 6:25870. Doi:10.1038/srep25870 [Link]

Słoniecka M, Le Roux S, Zhou Q, and Danielson P: Substance P enhances keratocyte migration and neutrophil recruitment through interleukin-8. Mol Pharmacol 2016; 89; 215-225 [Link]

Le Roux S, Borbely G, Słoniecka M, Backman LJ, and Danielson P: Transforming growth factor-beta1 modulates the functional expression of the neurokinin-1 receptor in human keratocytes. Current Eye Research 2016; 41; 1035-1043 [Link]

Słoniecka M, Backman LJ, Danielson P: Acetylcholine enhances keratocyte proliferation through muscarinic receptor activation. International Immunopharmacology 2015; 29; 57-62 [Link]

Słoniecka M, Le Roux S, Boman P, Byström B, Zhou Q, and Danielson P: Expression profiles of neuropeptides, neurotransmitters, and their receptors in human keratocytes in vitro and in situPLoS ONE 2015; 10(7): e0134157. [Link]

Jonsson F, Byström B, Davidson AE, Backman LJ, Kellgren TG, Tuft SJ, Koskela T, Rydén P, Sandgren O, Danielson P, Hardcastle AJ, Golovleva I: Mutations in Collagen, type XVII, Alpha 1 (COL17A) Cause Epithelial Recurrent Erosion Dystrophy (ERED). Human Mutation 2015; 36; 463-473 [Link]

Yang L, Di G, Qi X, Qu M, Wang Y, Duan H, Danielson P, Xie L, and Zhou Q: Substance P promotes diabetic corneal epithelial wound healing through molecular mechanisms mediated via the neurokinin-1 receptor. Diabetes 2014; 63; 4262-4274 [Link]

Backman LJ, Eriksson DE, Danielson P: Substance P reduces TNF-α-induced apoptosis in human tenocytes through NK-1 receptor stimulation. Br J Sports Med 2014; 48; 1414-1420 [Link]

Backman LJ and Danielson P: Akt-mediated anti-apoptotic effects of substance P in Anti-Fas induced apoptosis of human tenocytes. J Cell Mol Med 2013; 17; 723-733 [Link]

Yang L, Qu M, Wang Y, Duan H, Chen P, Wang Y, Shi W, Danielson P¤
and Zhou Q¤: Trichostatin A Inihibits TGF-β-induced Reactive Oxygen Species Accumulation and Myofibroblast Differentiation Via Enhanced Nrf2-ARE Signaling. Mol Pharmacol 2013; 83; 671-680 [Link]
(¤=contributed equally to the design and preparation of the manuscript)

Danielson P and Scott A: Editorial – Teaming up to beat tendon pain: clinical and research excellence own the podium at ISTS (International Scientific Tendinopathy Symposium). Br J Sports Med 2013; 47; 532 [Link]

Scott A, Docking S, Vicenzino B, Alfredson H, Murphy RJ, Carr AJ, Zwerver J, Lundgren K, Finlay O, Pollock N, Cook JL, Fearon A, Purdam CR, Hoens A, Rees JD, Goetz T, and Danielson P: Consensus statement – Sports and exercise-related tendinopathies: a review of selected topical issues by participants of the second International Scientific Tendinopathy Symposium (ISTS) Vancouver 2012. Br J Sports Med 2013; 47; 536-544 [Link]

Fong G, Backman LJ, Hart DA, Danielson P, McCormack, and Scott A: Substance P Enhances Collagen Remodelling and MMP-3 Expression By Human Tenocytes. J Orthop Res 2013; 31; 91-98  [Link]

Fong G, Backman LJ, Andersson G, Scott A, and Danielson P: Human Tenocytes Are Stimulated to Proliferate by Acetylcholine through an EGFR Signalling Pathway. Cell Tiss Res 2013; 351; 465-475 [Link]

Bagge J, Danielson P and Forsgren S: In situ hybridization studies favouring the occurrence of a local production of BDNF in the human Achilles tendon. Histol Histopathol 2012; 27; 1239-1246 [Link]

Backman LJ, Andersson G, Fong G, Alfredson H, Scott A, and Danielson P: Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: comparison between two model systems. Scand J Med Sci Sports 2013; 23; 687-696 [Link]

Backman LJ, Fong G, Andersson G, Scott A, and Danielson P: Substance P Is a Mechanoresponsive, Autocrine Regulator of Human Tenocyte Proliferation. PLoS ONE2011; 6; e27209 [Link]

Backman LJ and Danielson P: Low range of ankle dorsiflexion predisposes for patellar tendinopathy in junior elite basketball players: A one-year prospective study. Am J Sports Med 2011; 39; 2626-33 [Link]

Bagge J, Gaida JE, Danielson P, Alfredson H, and Forsgren S: Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors – A pilot study. Scand J Med Sci Sports 2011; 21; e430-438 [Link]

Scott A, Danielson P, Abraham T, Fong G, Sampaio A, and Underhill TM: Mechanical force modulates scleraxis expression in bioartificial tendons. J Musculoskelet Neuronal Interact 2011; 11; 124-32 [Link]

Backman LJ, Andersson G, Wennstig G, Forsgren S, and Danielson P: Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy: peptidergic elevation preceding tendinosis-like tissue changes. J Musculoskelet Neuronal Interact 2011; 11; 133-40 [Link]

Andersson G, Backman LJ, Scott A, Lorentzon R, Forsgren S and Danielson P: Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model. Br J Sports Med 2011; 45; 1017-1022 [Link]

Spang C, Scott A, Danielson P, Lorentzon R, and Forsgren S: VGluT2 and NMDAR-1 expression in inflammatory infiltrates in experimentally induced myositis: Evidence of local glutamate signaling suggests autocrine/paracrine effects in an overuse injury model. Inflammation 2012; 35; 39-48 [Link]

Andersson G, Forsgren S, Scott A, Gaida JE, Elgestad Stjernfeldt J, Lorentzon R, Alfredson H, Backman C, and Danielson P: Tenocyte hypercellularity and vascular proliferation in a rabbit model of tendinopathy: contralateral effects suggest the involvement of central neuronal mechanisms. Br J Sports Med 2011; 45; 399-406 [Link]

Forsgren S, Alfredson H, Bjur D, Rantapää-Dahlqvist S, Norrgård Ö, Dalén T, and Danielson P: Novel information on the non-neuronal cholinergic system in orthopedics provides new possible treatment strategies for inflammatory and degenerative diseases. Orthopedic Reviews 2009; 1; 39-46 [Link]

Scott A and Danielson P: An Emerging Role for Angiogenesis in Tendinopathy. European Musculoskeletal Review 2009; 4, 75-6 [Link]

Forsgren S, Grimsholm O, Jönsson M, Alfredson H, and Danielson P: New insight into the non-neuronal cholinergic system via studies on chronically painful tendons and inflammatory situations. Life Sciences 2009; 84; 25-6 [Link]

Zeisig E, Ljung B-O, Alfredson H, and Danielson P: Immunohistochemical evidence of local production of catecholamines in cells of the muscle origins at the lateral and medial humeral epicondyles: of importance for the development of tennis and golfer's elbow? Br J Sports Med 2009; 43; 269-75 [Link]

Danielson P: Reviving the "biochemical" hypothesis for tendinopathy: new findings suggest the involvement of locally produced signal substances. Br J Sports Med 2009; 43; 265-8 [Link]

Andersson G, Danielson P, Alfredson H, Forsgren S: Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon. Regul Pept 2008; 150; 81-7 [Link]

Danielson P, Andersson G, Alfredson H, Forsgren S: Marked sympathetic component in the perivascular innervation of the dorsal paratendinous tissue of the patellar tendon in arthroscopically treated tendinosis patients. Knee Surg Sports Traumatol Arthrosc 2008; 16; 621-6 [Link]

Bjur D, Danielson P, Alfredson H, Forsgren S: Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance concerning Achilles tendon tendinosis (tendinopathy). Cell and Tissue Research 2008; 331; 385-400 [Link]

Bjur D, Danielson P, Alfredson H, Forsgren S: Immunohistochemical and in situ hybridization observations favor a local catecholamine production in the human Achilles tendon. Histology and Histopathology 2008; 23; 197-208 [Link]

Andersson G, Danielson P, Alfredson H, Forsgren S: Nerve-related characteristics of ventral paratendinous tissue in chronic Achilles tendinosis. Knee Surg Sports Traumatol Arthrosc 2007; 15: 1272-9 [Link]

Danielson P, Alfredson H, Forsgren S: In situ hybridization studies confirming recent findings of the existence of a local non-neuronal catecholamine production in human patellar tendinosis. Microsc Res Tech 2007; 70: 908–11 [Link]

Danielson P, Alfredson H, Forsgren S: Studies on the importance of sympathetic innervation, adrenergic receptors and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man. Microsc Res Tech 2007; 70: 310-24 [Link]

Danielson P, Andersson G, Alfredson H, Forsgren S: Extensive expression of markers for acetylcholine synthesis and of M2 receptors in tenocytes in therapy-resistant chronic painful patellar tendon tendinosis – a pilot study. Life Sciences 2007; 80: 2235–8 [Link]

Danielson P, Alfredson H, Forsgren S: Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. Microsc Res Tech 2006; 69: 808-19 [Link]

Danielson P, Alfredson H, Forsgren S: Distribution of general (PGP 9.5) and sensory (substance P/CGRP) innervations in the human patellar tendon. Knee Surg Sports Traumatol Arthrosc 2006; 14: 125-32 [Link]

Forsgren S, Danielson P, Alfredson H: Vascular NK-1 receptor occurrence in normal and chronic painful Achilles and patellar tendons: studies on chemically unfixed as well as fixed specimens. Regul Pept 2005; 126: 173-81 [Link]

Other Publications:

Danielson P, Scott A: Biological Causes in Patellar Tendinopathy. In: Anterior Knee Pain 2nd ed. 2011 Editor: Vicente Sanchis-Alfonso; Spriger-Verlag, London. pp. 229-236 [Link]

Danielson P: Är "nervsignalsubstanser utan nerver" svaret på tendinopatins gåta? – om en muskelsenas förvandling vid kroniska smärttillstånd. Svensk Idrottsforskning: Organ för Centrum för Idrottsforskning 2009, Årgång 18, nr 1; 50-2 [Link]

Forsgren S, Andersson G, Bjur D, and Danielson P: Senvävnad utan nerver. Svensk Idrottsforskning: Organ för Centrum för Idrottsforskning 2011; Årgång 20, nr 1; 72-5 [Link]

Forsgren S, Bjur D, Danielson P, Alfredson H: Den kroniskt smärtande senan – histopatologi. In: Idrottsskador – frontlinjen inom behandling och rehabilitering 2007; Centrum för idrottsforskning, Trydells tryckeri, Laholm, sid 267-274

Forsgren S, Bjur D, Danielson P, Alfredson H: Förändringar i kroniskt smärtande sena. Svensk IdrottsMedicin: Organ för svensk Idrottsmedicinsk Förening 2006, Årgång 25, nr 3; 8-10

Thesis:

Innervation patterns and locally produced signal substances in the human patellar tendon – of importance when understanding the processes of tendinosis, Umeå 2007 [Full-text]


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901 87 Umeå 

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