Patrik Danielson

Title: M.D., Ph.D., Associate Professor
[sv. Leg. läkare, Med.dr, Univ.lektor, Docent]
Principal Investigator

Address: Dept. of Integrative Medical Biology,
Section for Anatomy,
Umeå University, SE-901 87 Umeå, Sweden

Phone: +46 (0)90 786 58 93 (office)
+46 (0)70 336 80 30 (mobile)

Fax: +46 (0)90 786 67 07

E-mail: patrik.danielsonanatomy.umu.se

Patrik Danielson is associate professor of anatomy at Umeå University and resident physician in ophthalmology/ophthalmic surgery [sv. ST-läkare, ögonsjukdomar] at the University Hospital of Umeå. He is the principal investigator of the experimental connective tissue research projects of the Neuropeptide Research Team.

Dr. Danielson's research group consists of:
Doctoral students Ludvig Backman and Gloria Fong, postdocs Gustav Andersson and Sandrine Le Roux, and research assistant Peter Boman. Ulla Hedlund is the lab techincian for the group.

Dr. Danielson is furthermore assistant supervisor of doctoral student Johan Bagge.

Dr. Danielson's research revolves diseases in collagen rich tissues, with focus on muscle tendons and the cornea of the eye. The aim of this research is to unravel the possible roles of locally produced signal substances, traditionally attributed to neuronal signalling mechanisms, in the development of connective tissue pathology.
This research is performed in collaboration with the the Dept. of Surgical and Perioperative Science, Sports Medicine, and the Dept. of Clinical Sciences, Ophthalmology, Umeå University, as well as with the University of British Columbia, Vancouver, Canada (Assist. Prof. Alex Scott), and the Shandong Eye Institute, Qingdao, China (Assoc. Prof. Qingjun Zhou).
Read more about this research on the research team website or in the university's research database (information in both Swedish and English is available).

Press clipping about the tendon research (pdf-file, in Swedish).

CURRICULUM VITAE

*) National Swedish Research Council

PUBLICATIONS (peer-reviewed scientific papers):

Bagge J, Danielson P and Forsgren S: In situ hybridization studies favouring the occurrence of a local production of BDNF in the human Achilles tendon. Histol Histopathol. Accepted for publication Feb 6, 2012 (in print)

Backman LJ, Andersson G, Fong G, Alfredson H, Scott A, and Danielson P: Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: comparison between two model systems. Scand J Med Sci Sports. Published online first: Jan 31, 2012; DOI:10.1111/j.1600-0838.2011.01442.x [Link]

Backman LJ, Fong G, Andersson G, Scott A, and Danielson P: Substance P Is a Mechanoresponsive, Autocrine Regulator of Human Tenocyte Proliferation. PLoS ONE 2011; 6; e27209 [Link]

Backman LJ and Danielson P: Low range of ankle dorsiflexion predisposes for patellar tendinopathy in junior elite basketball players: A one-year prospective study. Am J Sports Med 2011; 39; 2626-33 [Link]

Bagge J, Gaida JE, Danielson P, Alfredson H, and Forsgren S: Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors – A pilot study. Scand J Med Sci Sports 2011; 21; e430-438 [Link]

Scott A, Danielson P, Abraham T, Fong G, Sampaio A, and Underhill TM: Mechanical force modulates scleraxis expression in bioartificial tendons. J Musculoskelet Neuronal Interact 2011; 11; 124-32 [Link]

Backman LJ, Andersson G, Wennstig G, Forsgren S, and Danielson P: Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy: peptidergic elevation preceding tendinosis-like tissue changes. J Musculoskelet Neuronal Interact 2011; 11; 133-40 [Link]

Andersson G, Backman LJ, Scott A, Lorentzon R, Forsgren S and Danielson P: Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model. Br J Sports Med 2011; 45; 1017-1022 [Link]

Spang C, Scott A, Danielson P, Lorentzon R, and Forsgren S: VGluT2 and NMDAR-1 expression in inflammatory infiltrates in experimentally induced myositis: Evidence of local glutamate signaling suggests autocrine/paracrine effects in an overuse injury model. Inflammation 2010; Online First, published December 31 2010, doi:10.1007/s10753-010-9287-z [Link]

Andersson G, Forsgren S, Scott A, Gaida JE, Elgestad Stjernfeldt J, Lorentzon R, Alfredson H, Backman C, and Danielson P: Tenocyte hypercellularity and vascular proliferation in a rabbit model of tendinopathy: contralateral effects suggest the involvement of central neuronal mechanisms. Br J Sports Med 2011; 45; 399-406 [Link]

Forsgren S, Alfredson H, Bjur D, Rantapää-Dahlqvist S, Norrgård Ö, Dalén T, and Danielson P: Novel information on the non-neuronal cholinergic system in orthopedics provides new possible treatment strategies for inflammatory and degenerative diseases. Orthopedic Reviews 2009; 1; 39-46 [Link]

Scott A and Danielson P: An Emerging Role for Angiogenesis in Tendinopathy. European Musculoskeletal Review 2009; 4, 75-6 [Link]

Forsgren S, Grimsholm O, Jönsson M, Alfredson H, and Danielson P: New insight into the non-neuronal cholinergic system via studies on chronically painful tendons and inflammatory situations. Life Sciences 2009; 84; 25-6 [Link]

Zeisig E, Ljung B-O, Alfredson H, and Danielson P: Immunohistochemical evidence of local production of catecholamines in cells of the muscle origins at the lateral and medial humeral epicondyles: of importance for the development of tennis and golfer's elbow? Br J Sports Med 2009; 43; 269-75 [Link]

Danielson P: Reviving the "biochemical" hypothesis for tendinopathy: new findings suggest the involvement of locally produced signal substances. Br J Sports Med 2009; 43; 265-8 [Link]

Andersson G, Danielson P, Alfredson H, Forsgren S: Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon. Regul Pept 2008; 150; 81-7 [Link]

Danielson P, Andersson G, Alfredson H, Forsgren S: Marked sympathetic component in the perivascular innervation of the dorsal paratendinous tissue of the patellar tendon in arthroscopically treated tendinosis patients. Knee Surg Sports Traumatol Arthrosc 2008; 16; 621-6 [Link]

Bjur D, Danielson P, Alfredson H, Forsgren S: Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance concerning Achilles tendon tendinosis (tendinopathy). Cell and Tissue Research 2008; 331; 385-400 [Link]

Bjur D, Danielson P, Alfredson H, Forsgren S: Immunohistochemical and in situ hybridization observations favor a local catecholamine production in the human Achilles tendon. Histology and Histopathology 2008; 23; 197-208 [Link]

Andersson G, Danielson P, Alfredson H, Forsgren S: Nerve-related characteristics of ventral paratendinous tissue in chronic Achilles tendinosis. Knee Surg Sports Traumatol Arthrosc 2007; 15: 1272-9 [Link]

Danielson P, Alfredson H, Forsgren S: In situ hybridization studies confirming recent findings of the existence of a local non-neuronal catecholamine production in human patellar tendinosis. Microsc Res Tech 2007; 70: 908–11 [Link]

Danielson P, Alfredson H, Forsgren S: Studies on the importance of sympathetic innervation, adrenergic receptors and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man. Microsc Res Tech 2007; 70: 310-24 [Link]

Danielson P, Andersson G, Alfredson H, Forsgren S: Extensive expression of markers for acetylcholine synthesis and of M2 receptors in tenocytes in therapy-resistant chronic painful patellar tendon tendinosis – a pilot study. Life Sciences 2007; 80: 2235–8 [Link]

Danielson P, Alfredson H, Forsgren S: Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. Microsc Res Tech 2006; 69: 808-19 [Link]

Danielson P, Alfredson H, Forsgren S: Distribution of general (PGP 9.5) and sensory (substance P/CGRP) innervations in the human patellar tendon. Knee Surg Sports Traumatol Arthrosc 2006; 14: 125-32 [Link]

Forsgren S, Danielson P, Alfredson H: Vascular NK-1 receptor occurrence in normal and chronic painful Achilles and patellar tendons: studies on chemically unfixed as well as fixed specimens. Regul Pept 2005; 126: 173-81 [Link]

Other Publications:

Danielson P, Scott A: Biological Causes in Patellar Tendinopathy. In: Anterior Knee Pain 2nd ed. 2011 Editor: Vicente Sanchis-Alfonso; Spriger-Verlag, London [Link]

Danielson P: Är "nervsignalsubstanser utan nerver" svaret på tendinopatins gåta? – om en muskelsenas förvandling vid kroniska smärttillstånd. Svensk Idrottsforskning: Organ för Centrum för Idrottsforskning 2009, Årgång 18, nr 1; 50-2 [Link]

Forsgren S, Andersson G, Bjur D, and Danielson P: Senvävnad utan nerver. Svensk Idrottsforskning: Organ för Centrum för Idrottsforskning 2011; Årgång 20, nr 1; 72-5 [Link]

Forsgren S, Bjur D, Danielson P, Alfredson H: Den kroniskt smärtande senan – histopatologi. In: Idrottsskador – frontlinjen inom behandling och rehabilitering 2007; Centrum för idrottsforskning, Trydells tryckeri, Laholm, sid 267-274

Forsgren S, Bjur D, Danielson P, Alfredson H: Förändringar i kroniskt smärtande sena. Svensk IdrottsMedicin: Organ för svensk Idrottsmedicinsk Förening 2006, Årgång 25, nr 3; 8-10

Thesis:

Innervation patterns and locally produced signal substances in the human patellar tendon – of importance when understanding the processes of tendinosis, Umeå 2007 [Full-text]
  

Page Editor: Anita Dreyer Perkiömäki
2012-03-20