Christoph Spang

Title: M.Sc. (Biology), M.Sc. (Sports science),
Ph.D. (Medical Science, Anatomy),
Post-doctoral Researcher

Address: Dept. of Integrative Medical Biology,
Umeå University, SE-901 87 Umeå, Sweden



Research area of interest: Interferences between the plantaris and Achilles tendons in mid portion Achilles tendinopathy.


PUBLICATIONS (peer-reviewed scientific papers):

Spang C, Renström L, Alfredson H, Forsgren S. Marked expression of TNF receptors in human peritendinous tissues including in nerve fascicles with axonal damage - Studies on tendinopathy and tennis elbow. J Musculoskelet Neuronal Interact. 2017 Sep 1;17(3):226-236. [Link]

Alfredson H, Spang C. Clinical presentation and surgical management of chronic Achilles tendon disorders — A retrospective observation on a set of consecutive patients being operated by the same orthopaedic surgeon. Foot Ankle Surg. in press [Link]

Spang C, Alfredson H: Richly innervated soft tissues covering the superficial aspect of the extensor origin in patients with chronic painful tennis elbow - Implication for treatment? J Musculoskelet Neuronal Interact 2017; 17(2): 97-103. [Link]

Abat F, Alfredson H, Cucchiarini M, Madry H, Marmotti A, Mouton C, Oliveira JM, Pereira H, Peretti GM, Romero-Rodriguez D, Spang C, Stephen J, van Bergen CJA, de Girolamo L: Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach. J Exp Orthop 2017; 4(1): 18. [Link]

Spang C, Backman LJ, Le Roux S, Chen J, and Danielson P: Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells. BMC Musculoskeletal Disorders May 12, 2017; 18: 218. [Link]

Spang C, Chen J, Backman LJ. The tenocyte phenotype of human primary tendon cells in vitro is reduced by glucocorticoids. BMC Musculoskelet Disord. 2016, 17:467. [Link]

Spang C, Alfredson H, Docking SI, Masci L, Andersson G. The plantaris tendon: a narrative review focusing on anatomical features and clinical importance. Bone Joint J. 2016; 98-B(10): 1312-9. Review. [Link]

Masci L, Spang C, van Schie HT, Alfredson H: How to diagnose plantaris tendon involvement in midportion Achilles tendinopathy - clinical and imaging findings. BMC Musculoskeletal Disord. 2016, 17(1):97. [Link]

Spang C, Forsgren S. Choline acetyltransferase and the nicotinic acetylcholine receptor AChRα7 in experimental myositis. Int Immunopharmacol. 2015; Jun 15. Epub ahead of print. [Link]

Spang C, Harandi VM, Alfredson H, Forsgren S. Marked innervation but also signs of nerve degeneration in between the Achilles and plantaris tendons and presence of innervation within the plantaris tendon in midportion Achilles tendinopathy. J Musculoskelet Neuronal Interact2015; 15(2): 197-206. [Link]

Masci L, Spang C, van Schie H, Alfredson H. Achilles tendinopathy – Do plantaris tendon removal and Achilles scraping improve tendon structure? A prospective study using Ultrasound Tissue Characterisation. BMJ Open Sp Ex Med. 2015 1: e000005 doi:10.1136/bmjsem-2015-000005 [Link]

Alfredson H, Spang C, Forsgren S. Unilateral surgical treatment for patients with midportion Achilles tendinopathy may result in bilateral recovery. Br J Sports Med2014; 48(19): 1421-4 [Link]

Spang C, Alfredson H, Ferguson M, Roos B, Bagge J, Forsgren S. The plantaris tendon in association with mid-portion Achilles tendinosis - Tendinosis-like morphological features and presence of a non-neuronal cholinergic system. Histol Histopathol. 2013 Feb 4 (E-pub ahead of print) [Link]

Spang C, Scott A, Danielson P, Lorentzon R, and Forsgren S: VGluT2 and NMDAR1 expression in cells in the inflammatory infiltrates in experimentally induced myositis: evidence of local glutamate signaling suggests autocrine/paracrine effects in an overuse injury model. Inflammation. 2012; 35(1): 39-48. [Link]